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KMID : 0391119930020020098
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Ulsan University Medical Journal
1993 Volume.2 No. 2 p.98 ~ p.104
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Corneal graft rejuection reaction in the rat penetrating keratoplasty model
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Abstract
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Penetrating keratoplasty in inbred Lewis rat with either Lewis donor corneas (syngeneic transplantation group) or Brown Norway donor corneas(disparate transplantatio group) were performed. The kinetic changes of the inflammatory cell subtypes in
the
corneal transplantation site and the clinical features were studies.
All grafts(10 grafts) were remained clear in the syngeneic group. There was a significant inflammatory reaction in the wound especially surrounding the sutures. There cells were mostly macrophages(OX-42). This response in the wound progressively
diminished by third week. Rare T helper/inducer cells(W3/25) were noted in the graft early. By the second week this response in the graft and resolved.
Nine grafts out of 10 were rejected by the third week in the disparate group. Macrophages were ween in moderate numbers in the graft and wound during the first week. By the second week T helper/inducer cells and T suppressor/cytotoxic cells
(OX-8)
increased. In third or fourth week T suppressor/cytotoxic cells were most prominent cells in the rejected graft. The ratio of these three cell types(T suppressor/cytotoxic: T helper/inducer cell: macrophage) in the rejected cornea was 1.5:1:0.8.
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